Acetyl Chloride UPD
The albumin-bound nonesterified fatty acid pool in plasma, which represents a very small percentage of total plasma fatty acids, has previously been quantitated by a variety of methods. In the present study we determined that the nonesterified fatty acid concentrations in the plasma, quantitated by a popular method using acetyl chloride and methanol which is reported to be specific for methylation of nonesterified fatty acids in the presence of esterified fatty acids (i.e., without prior isolation of the plasma nonesterified fatty acids), were significantly overestimated due to cleavage and methylation of esterified fatty acids. Quantitation of the contaminating fatty acid from the esterified pool demonstrated that the amount of fatty acid cleaved from the esterified pool was enough to exceed the entire mass of nonesterified fatty acids. As an established method for comparison, we isolated nonesterified fatty acids from the plasma by thin-layer chromatography prior to methylation, using a number of simple precautions to limit oxidation. By performing all thin-layer chromatography steps in an atmosphere of nitrogen and by including fatty acid standards in the plasma with 0, 1, 2 or 4 double bonds, we were able to accurately and reproducibly determine the concentration of nonesterified fatty acids in the plasma, including arachidonate. We demonstrated that no oxidation occurred in the thin-layer chromatographic isolation of nonesterified fatty acids and that the coefficients of variation for repeat measurements of the same sample were
Acetyl chloride (CH3COCl) is an acyl chloride derived from acetic acid (CH3COOH). It belongs to the class of organic compounds called acid halides. It is a colorless, corrosive, volatile liquid. Its formula is commonly abbreviated to AcCl. Wikipedia
Acetyl chloride, CH3COCl is an acid chloride derived from acetic acid. It belongs to class of organic compounds called acyl halides. It is a colorless, corrosive, volatile liquid. Aquapharm manufactures and supplies high purity acetyl chloride.
Acetyl chloride acts as a reagent for the preparation of esters and amides of acetic acid. It is also useful an important reactant in Friedel-Crafts reactions as well as the introduction of an acetyl group. It serves as a starting material in the production of pharmaceutical, new plating complexing agent, acylation agent and synthetic organic intermediates.
Indorkar, D.; Chourasia, O. P.; Limaye, S. N. Original Research Article Synthesis and Characterization of some new Synthesis of 1-acetyl-3-(4-nitrophenyl)-5-(substituted phenyl) pyrazoline Derivative and antimicrobial activity. Int. J. Curr. Microbiol. App. Sci. 2015, 4 (2), 670-678.
Acetyl chloride is an acid chloride reagent used for acetylation in organic synthesis reactions such as esterification and the Friedel-Crafts reaction. It has been reported that Acetyl chloride can be used as a fluorescence histochemical in combination with formaldehyde to identify tryptophyl-peptide-containing endocrine cells of the hypophysis. Furthermore, gaseous Acetyl chloride can be used in Fourier-transform infrared emission spectroscopy at 248nm, which can detect fragments of HCl, CO, and CH2 in the presence of Ar or O2. Alternate studies suggest that Acetyl chloride can be used as a derivatizing agent for determining high molecular weight alcohols in fish oil.
The hydrolysis of acetyl chloride in mixed solvent of acetone-water was investigated by means of an electrical conductance method. The temperature was varied over the range of -35C to +10c, and the solvent composition was varied over the range of 10 to 25% of water by volume. The reaction was found to be first order with respect to water and first order with respect to acetyl chloride over the range investigated. A strong dielectric constant influence was found, manifesting itself in an influence on the isodielectric entropy of activation. This effect was consistent with electrostatic theory and followed the dipole-dipole type of dielectric constant dependence. The dipole moment of the activated complex was estimated to be 16 debyes.
Recognizing that there are practical considerations which make it difficult to place acetic anhydride or acetyl-chloride under strict national legislative control, particularly in countries where acetic anhydride or acetyl-chloride is used in large quantities industrially,
Draws the attention of Governments to the usefulness of taking all possible measures of supervision over the manufacture, movement and sale (in particular, in portable containers), as well as the use, of acetic anhydride or acetyl-chloride to prevent their availability for use in the illicit manufacture of heroin. 041b061a72